Effects of brominated emerging flame retardants in juvenile rainbow trout

Effects of brominated emerging flame retardants in juvenile rainbow trout In this study, the chronic effects of two emerging brominated flame retardants, 1,2-bis(2,4,6-tribromophenoxy)ethane(BTBPE) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) were evaluated in diet exposed juvenile rainbow trout(Oncorhynchus mykiss). FIsh uptake was measured after 28-d of exposure. Liver gene transcription analysis using RNA-sequencing was also performed, complemented by qRT-PCR to measure transcription levels of genes related to the immune response in the liver and the head kidney. Lysozyme enzymatic activity was also measured in head kidneys of exposed fish. Results were published in a peer-reviewed scientific publication that can be found here: https://doi.org/10.1016/j.aquatox.2017.02.023 2022-01-24 Environment and Climate Change Canada open-ouvert@tbs-sct.gc.ca Nature and EnvironmentToxicologyToxic substancesFreshwater fishFishBiologyGenomicsChemistryAquatic animalsrainbow troutflame retardantsBTBPEEHTBBimmune responselysozymeRNA-sequencingGenomics R&D Initiative (GRDI)Strategic Technology Applications of Genomics in the Environment (STAGE)Chemical Management Plan (CMP)gene transcriptionchronic toxicityfood-borne exposure View ECCC Data Mart (English)HTML https://donnees-data.ec.gc.ca/data/substances/assess/effects-of-brominated-emerging-flame-retardants-in-juvenile-rainbow-trout/?lang=en View ECCC Data Mart (French)HTML https://donnees-data.ec.gc.ca/data/substances/assess/effects-of-brominated-emerging-flame-retardants-in-juvenile-rainbow-trout/?lang=fr

In this study, the chronic effects of two emerging brominated flame retardants, 1,2-bis(2,4,6-tribromophenoxy)ethane(BTBPE) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) were evaluated in diet exposed juvenile rainbow trout(Oncorhynchus mykiss). FIsh uptake was measured after 28-d of exposure. Liver gene transcription analysis using RNA-sequencing was also performed, complemented by qRT-PCR to measure transcription levels of genes related to the immune response in the liver and the head kidney. Lysozyme enzymatic activity was also measured in head kidneys of exposed fish. Results were published in a peer-reviewed scientific publication that can be found here: https://doi.org/10.1016/j.aquatox.2017.02.023

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Quebec - Montréal
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