Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug Interaction

Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug Interaction Health Canada carried out a safety review after learning that the European Medicines Agency was looking into a potential interaction between levetiracetam and methotrexate. The interaction between the two drugs may lead to higher amount of methotrexate in the blood, which may cause serious side effects. The side effects, which can be fatal, include sudden (acute) kidney failure. 2024-05-09 Health Canada open-ouvert@tbs-sct.gc.ca Health and SafetySummary Safety ReviewLevetiracetamMethotrexateassessingpotential riskDrug-Drug Interaction Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug InteractionHTML https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/summary-safety-review-levetiracetam-methotrexate-assessing-potential-risk-drug.html Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug InteractionHTML https://www.canada.ca/fr/sante-canada/services/medicaments-produits-sante/medeffet-canada/examens-innocuite/resume-examen-innocuite-levetiracetam-methotrexate-evaluation-risque.html

Health Canada carried out a safety review after learning that the European Medicines Agency was looking into a potential interaction between levetiracetam and methotrexate. The interaction between the two drugs may lead to higher amount of methotrexate in the blood, which may cause serious side effects. The side effects, which can be fatal, include sudden (acute) kidney failure.

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