Summary Safety Review - Benzodiazepines and barbiturates - Assessing the potential risk of negative effects on the development of children’s brains (neurodevelopmental disorders)

Summary Safety Review - Benzodiazepines and barbiturates - Assessing the potential risk of negative effects on the development of children’s brains (neurodevelopmental disorders) The Canadian product safety information for lorazepam and midazolam warn that they should not be used during pregnancy. The Canadian product safety information for phenobarbital warns that during pregnancy the drug’s benefit should be weighed against its risk. Also, restrictions for use in children vary from one drug to another. 2024-05-08 Health Canada open-ouvert@tbs-sct.gc.ca Health and SafetySummary Safety ReviewBenzodiazepinesbarbituratesassessingpotential risknegative effectsdevelopment of children’s-brainsneurodevelopmental disorderslorazepammidazolamphenobarbitalduring pregnancydrug’s benefitrestrictions-for-use in children Summary Safety Review - Benzodiazepines and barbiturates - Assessing the potential risk of negative effects on the development of children’s brains (neurodevelopmental disorders)HTML https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/benzodiazepines-barbiturates-assessing-potential-risk-negative-effects-development-children-brains.html Summary Safety Review - Benzodiazepines and barbiturates - Assessing the potential risk of negative effects on the development of children’s brains (neurodevelopmental disorders)HTML https://www.canada.ca/fr/sante-canada/services/medicaments-produits-sante/medeffet-canada/examens-innocuite/benzodiazepines-barbituriques-evaluation-risque-potentiel-effets-nefastes-developpement-cerveaux-enfants.html

The Canadian product safety information for lorazepam and midazolam warn that they should not be used during pregnancy. The Canadian product safety information for phenobarbital warns that during pregnancy the drug’s benefit should be weighed against its risk. Also, restrictions for use in children vary from one drug to another.

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