Metformin: Environmental fate and effects study

Metformin: Environmental fate and effects study This study will determine the toxic effect the pharmaceutical metformin has on an aquatic environment. Chronic exposures were conducted at Lake 114 located at the International Institute for Sustainable Development-Experimental Lakes Area (IILSD-ELA) in Ontario, Canada. Three concentrations of metformin were used to study the effects on the adult and embryo life stages of the fathead minnow (Pimephales promelas) as well as the effect on the food chain within the mesocosms. Water samples for basic chemistry and nutrient samples were collected throughout the exposures. There is currently one publication and the authors plan to submit two more manuscripts from this research project. All data are a part subject of a publication containing method details, full QA/QC, interpretations and conclusions. Citation: Nielsen, K. M., DeCamp, L., Birgisson, M., Palace, V. P., Kidd, K. A., Parrott, J. L., McMaster, M. E., Alaee, M., Blandford, N., & Ussery, E. J. (2022). Comparative Effects of Embryonic Metformin Exposure on Wild and Laboratory-Spawned Fathead Minnow (Pimephales promelas) Populations. Environmental science & technology, 56(14), 10193–10203. doi.org/10.1021/acs.est.2c01079 Supplemental Information Supporting projects: Chemicals Management Plan (CMP) The Chemicals Management Plan (CMP) is a Government of Canada initiative aimed at reducing the risks posed by chemicals to Canadians and their environment. A key element of the Chemicals Management Plan is the monitoring and surveillance of levels of harmful chemicals in Canadians and their environment. Monitoring and surveillance are essential to identify and track exposure to hazards in the environment and associated health implications. Monitoring and surveillance programs provide the basis for making sound and effective public health and environmental health policies and interventions, as well as measuring the efficacy of control measures. In support of the Chemicals Management Plan, monitoring and surveillance initiatives were established to support Health Canada and Environment and Climate Change Canada scientists, in collaboration with external partners and researchers, to advance our knowledge. This initiative has allowed the Government of Canada to increase its commitment to a number of existing monitoring initiatives, as well as to support new efforts. For more information on the Chemicals Management Plan, please visit: https://www.canada.ca/en/health-canada/services/chemical-substances/chemicals-management-plan.html 2023-12-17 Environment and Climate Change Canada DRCADonnesOuvertes-ACRDOpenData@ec.gc.ca Nature and EnvironmentEnvironmentWatermetforminfathead minnow (Pimephales promelas)phytoplanktonzooplanktonecotoxicologypharmaceuticalsfreshwaterChemicals Management Plan (CMP) of Health CanadaNew Substances Assessment and Control Bureau (NSACB) View ECCC Data Mart (English)HTML https://data-donnees.az.ec.gc.ca/data/substances/monitor/metformin-environmental-fate-and-effects-study/?lang=en View ECCC Data Mart (French)HTML https://data-donnees.az.ec.gc.ca/data/substances/monitor/metformin-environmental-fate-and-effects-study/?lang=fr

This study will determine the toxic effect the pharmaceutical metformin has on an aquatic environment. Chronic exposures were conducted at Lake 114 located at the International Institute for Sustainable Development-Experimental Lakes Area (IILSD-ELA) in Ontario, Canada. Three concentrations of metformin were used to study the effects on the adult and embryo life stages of the fathead minnow (Pimephales promelas) as well as the effect on the food chain within the mesocosms. Water samples for basic chemistry and nutrient samples were collected throughout the exposures. There is currently one publication and the authors plan to submit two more manuscripts from this research project.

All data are a part subject of a publication containing method details, full QA/QC, interpretations and conclusions. Citation: Nielsen, K. M., DeCamp, L., Birgisson, M., Palace, V. P., Kidd, K. A., Parrott, J. L., McMaster, M. E., Alaee, M., Blandford, N., & Ussery, E. J. (2022). Comparative Effects of Embryonic Metformin Exposure on Wild and Laboratory-Spawned Fathead Minnow (Pimephales promelas) Populations. Environmental science & technology, 56(14), 10193–10203. doi.org/10.1021/acs.est.2c01079

Supplemental Information

Supporting projects: Chemicals Management Plan (CMP)

The Chemicals Management Plan (CMP) is a Government of Canada initiative aimed at reducing the risks posed by chemicals to Canadians and their environment. A key element of the Chemicals Management Plan is the monitoring and surveillance of levels of harmful chemicals in Canadians and their environment. Monitoring and surveillance are essential to identify and track exposure to hazards in the environment and associated health implications. Monitoring and surveillance programs provide the basis for making sound and effective public health and environmental health policies and interventions, as well as measuring the efficacy of control measures.

In support of the Chemicals Management Plan, monitoring and surveillance initiatives were established to support Health Canada and Environment and Climate Change Canada scientists, in collaboration with external partners and researchers, to advance our knowledge. This initiative has allowed the Government of Canada to increase its commitment to a number of existing monitoring initiatives, as well as to support new efforts.

For more information on the Chemicals Management Plan, please visit: https://www.canada.ca/en/health-canada/services/chemical-substances/chemicals-management-plan.html

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