Benzotriazole UV-stabilizers effects in juvenile rainbow trout

Benzotriazole UV-stabilizers effects in juvenile rainbow trout The objectives of the present study were to evaluate the chronixc effects of 2 BZT‐UVs alone and in a mixture, 2‐(2H‐benzotriazol‐2‐yl)‐4,6‐bis(1‐methyl‐1‐phenylethyl)phenol (UV‐234) and 2‐(2H‐benzotriazol‐2‐yl)‐4,6‐di‐tert‐pentylphenol (UV‐328), in juvenile rainbow trout (Oncorhynchus mykiss) chronically exposed (for 28 d) through the diet. Chemical analyses were used to measure liver accumulation of the 2 compounds in exposed trout. Hepatic RNA‐sequencing and qRT-PCR were used to measure gene transcription levels in exposed fish. Results were published in a scientific article that can be found here: https://doi.org/10.1002/etc.4676 2023-05-31 Environment and Climate Change Canada enviroinfo@ec.gc.ca Nature and EnvironmentAquatic animalsFishToxicologyToxic substancesBiologyGenomicsChemicalsFreshwater fishfishtoxicogenomicsRNA-sequencingmixture toxicologyiron homeostasisin vivo exposurerainbow troutGenomics R&D Initiative (GRDI)Strategic Technology Applications of Genomics in the Environment (STAGE)Chemical Management Plan (CMP)emerging contaminantsOncorhynchus mykissUV-234UV-328 View ECCC Data Mart (English)HTML https://donnees-data.ec.gc.ca/data/substances/assess/toxicity-of-benzotriazoles-in-aquatic-organisms/benzotriazole-uv-stabilizers-effects-in-juvenile-rainbow-trout/?lang=en View ECCC Data Mart (French)HTML https://donnees-data.ec.gc.ca/data/substances/assess/toxicity-of-benzotriazoles-in-aquatic-organisms/benzotriazole-uv-stabilizers-effects-in-juvenile-rainbow-trout/?lang=fr

The objectives of the present study were to evaluate the chronixc effects of 2 BZT‐UVs alone and in a mixture, 2‐(2H‐benzotriazol‐2‐yl)‐4,6‐bis(1‐methyl‐1‐phenylethyl)phenol (UV‐234) and 2‐(2H‐benzotriazol‐2‐yl)‐4,6‐di‐tert‐pentylphenol (UV‐328), in juvenile rainbow trout (Oncorhynchus mykiss) chronically exposed (for 28 d) through the diet. Chemical analyses were used to measure liver accumulation of the 2 compounds in exposed trout. Hepatic RNA‐sequencing and qRT-PCR were used to measure gene transcription levels in exposed fish.

Results were published in a scientific article that can be found here: https://doi.org/10.1002/etc.4676

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