The effects of pharmaceuticals on a unionid mussel (Lampsilis siliquoidea): An examination of acute and chronic endpoints of toxicity across life stages

The effects of pharmaceuticals on a unionid mussel (Lampsilis siliquoidea): An examination of acute and chronic endpoints of toxicity across life stages The toxicity and bioconcentration of 3 pharmaceuticals (amitriptyline, iopamidol, and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Glochidia and juveniles were more sensitive than adult mussels. However, the compounds examined were not toxic at concentrations detected in the environment. The results suggest that glochidia toxicity could be a screening tool for rapidly assessing the toxicity of chemicals of concern to freshwater mussels. Results were published in a scientific article that can be found here: https://doi.org/10.1002/etc.3683 2022-04-22 Environment and Climate Change Canada open-ouvert@tbs-sct.gc.ca Nature and EnvironmentAmitriptylineIopamidolSertralinePharmaceuticalsBioconcentrationFreshwater musselThe New Substances Assessment and Control Bureau (NSACB)Aquatic ecosystemsToxicology View ECCC Data Mart (English)HTML https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/?lang=en View ECCC Data Mart (French)HTML https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/?lang=fr NSACB_IOP_SER_AMI_AdultMussel_Behaviour_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_IOP_SER_AMI_AdultMussel_Behaviour_EN_FR.csv NSACB_IOP_SER_AMI_AdultMussel_Takedown_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_IOP_SER_AMI_AdultMussel_Takedown_EN_FR.csv NSACB_IOP_SER_AMI_JuvenileMussel_Behaviour_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_IOP_SER_AMI_JuvenileMussel_Behaviour_EN_FR.csv NSACB_IOP_SER_AMI_JuvenileMussel_Takedown_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_IOP_SER_AMI_JuvenileMussel_Takedown_EN_FR.csv NSACB_IOP_SER_AMI_MusselGlochidia_Viability_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_IOP_SER_AMI_MusselGlochidia_Viability_EN_FR.csv NSACB_SER_AMI_Mussel_ClearanceRate_EN_FR.csvCSV https://data-donnees.ec.gc.ca/data/substances/assess/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages/NSACB_SER_AMI_Mussel_ClearanceRate_EN_FR.csv

The toxicity and bioconcentration of 3 pharmaceuticals (amitriptyline, iopamidol, and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Glochidia and juveniles were more sensitive than adult mussels. However, the compounds examined were not toxic at concentrations detected in the environment. The results suggest that glochidia toxicity could be a screening tool for rapidly assessing the toxicity of chemicals of concern to freshwater mussels. Results were published in a scientific article that can be found here: https://doi.org/10.1002/etc.3683

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